Innovation in neglected tropical disease drug discovery and development
نویسندگان
چکیده
منابع مشابه
The Role of Natural Products in Drug Discovery and Development against Neglected Tropical Diseases.
Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect more than 1 billion people annually, including 875 million children in developing economies. These diseases are also responsible for over 500,000 deaths per year and are characterized by long-term disability and severe pain. The impact of the combined NTDs closely rivals that of malaria and tuberculosis...
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Patricia Gabriel, MD, is a family medicine resident at St. Paul’s Hospital, Vancouver, BC, Canada. Rebecca Goulding, PhD, is a postdoctoral fellow at the ISIS Research Centre, Sauder School of Business, University of British Columbia, Vancouver. Cecily Morgan-Jonker, BSc, is a medical student at the University of British Columbia. Shannon Turvey, MSc, is a medical student at the University of B...
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Neglected tropical diseases (NTDs) have seen a welcome bolstering of activities focused on discovery of new therapies for these diseases. By and large, NTD drug discovery happens in the nonprofit sector—in academic laboratories and in public–private partnerships—though there has also been a significant and tangible influx of data and research contributions from the for-profit biopharmaceutical ...
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New models of drug discovery have been developed to overcome the lack of modern and effective drugs for neglected diseases such as human African trypanosomiasis (HAT; sleeping sickness), leishmaniasis, and Chagas disease, which have no financial viability for the pharmaceutical industry. With the purpose of combining the skills and research capacity in academia, pharmaceutical industry, and con...
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Chromoblastomycosis (CMB) is a chronic fungal infection of the skin and the subcutaneous tissue caused by a transcutaneous traumatic inoculation of a specific group of dematiaceous fungi occurring mainly in tropical and subtropical zones worldwide. If not diagnosed at early stages, patients with CBM require long term therapy with systemic antifungals, sometimes associated with physical methods....
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ژورنال
عنوان ژورنال: Infectious Diseases of Poverty
سال: 2018
ISSN: 2049-9957
DOI: 10.1186/s40249-018-0444-1